Acetyl Isoleucyl D-Oligopeptide-1 Amide
A cosmetic ingredient used as antimicrobial, anti-sebum, preservative in skincare, haircare, and personal-care products sold in the European Union.
What is it?
Acetyl Isoleucyl D-Oligopeptide-1 Amide is the product obtained by the acetylation of the synthetic peptide containing 15 amino acids consisting of D-arginine, L-isoleucine, D-leucine, D-lysine, D-phenylalanine, D-tryptophan and D-valine in which the C-terminus is an amide. The L conformation of the oligopeptide is based on a 12 amino acid sequence from Vipericidin which is found in the eastern brown snake.
What does it do?
Acetyl Isoleucyl D-Oligopeptide-1 Amide is listed in the EU cosmetic ingredient inventory with the following declared functions:
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Antimicrobial
kills or inhibits the growth of microorganisms
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Anti-sebum
helps regulate or reduce excess sebum (oil) on the skin
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Preservative
prevents microbial growth in cosmetic products, extending shelf life and protecting users
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Skin conditioning - miscellaneous
improves skin condition through mechanisms not classified under the more specific emollient or humectant subcategories
EU regulatory status
Acetyl Isoleucyl D-Oligopeptide-1 Amide is allowed for use in cosmetic products in the European Union under Regulation 1223/2009. It is not subject to a specific Annex restriction at the time of writing.
Frequently asked questions
What is Acetyl Isoleucyl D-Oligopeptide-1 Amide?
Acetyl Isoleucyl D-Oligopeptide-1 Amide is a cosmetic ingredient catalogued in the EU CosIng database. Acetyl Isoleucyl D-Oligopeptide-1 Amide is the product obtained by the acetylation of the synthetic peptide containing 15 amino acids consisting of D-arginine, L-isoleucine, D-leucine, D-lysine, D-phenylalanine, D-tryptophan and D-valine in which the C-terminus is an amide. The L conformation of the oligopeptide is based on a 12 amino acid sequence from Vipericidin which is found in the eastern brown snake.
Is Acetyl Isoleucyl D-Oligopeptide-1 Amide allowed in cosmetics in the EU?
Yes. Acetyl Isoleucyl D-Oligopeptide-1 Amide is allowed for use in cosmetic products in the EU under Regulation 1223/2009.
What does Acetyl Isoleucyl D-Oligopeptide-1 Amide do in cosmetic products?
Acetyl Isoleucyl D-Oligopeptide-1 Amide is declared in the EU cosmetic ingredient inventory with these functions: antimicrobial, anti-sebum, preservative, skin conditioning - miscellaneous.
Related ingredients
Source: EU CosIng database (European Commission). This page is derived from public-sector information published by the European Commission. · Last updated: 15/05/2025