R-(Sh-Polypeptide-111 Oligopeptide-163 Sh-Polypeptide-117 Sh-Polypeptide-94 Sh-Polypeptide-95 Pentapeptide-63 Oligopeptide-163 Sh-Polypeptide-6) Dimer
A cosmetic ingredient used as skin conditioning, skin conditioning - emollient, skin protecting in skincare, haircare, and personal-care products sold in the European Union.
What is it?
This peptide is a dimer linked by a disulfide bridge between the cysteines, consisting of a single chain synthetic fusion peptide, produced by fermentation in Chinese Hamster Ovary (CHO). The starting gene is synthesized by the fusion of the gene from sh-Polypeptide-111, Oligopeptide-163, sh-Polypeptide-117, sh-Polypeptide-94, sh-Polypeptide-95, and Pentapeptide-63. This fusion protein binds to Immunoglobulin E (IgE) and Interleukin-10 (IL-10) receptors; and it contains 605 amino acids which may contain disulfide bonds and/or glycosylation, and consists of the proper sequence of the 20 amino acids.
What does it do?
R-(Sh-Polypeptide-111 Oligopeptide-163 Sh-Polypeptide-117 Sh-Polypeptide-94 Sh-Polypeptide-95 Pentapeptide-63 Oligopeptide-163 Sh-Polypeptide-6) Dimer is listed in the EU cosmetic ingredient inventory with the following declared functions:
-
Skin conditioning
improves the appearance, feel, and condition of skin
-
Skin conditioning - emollient
softens the skin by reducing roughness and friction between skin cells
-
Skin protecting
helps shield skin from external environmental factors
EU regulatory status
R-(Sh-Polypeptide-111 Oligopeptide-163 Sh-Polypeptide-117 Sh-Polypeptide-94 Sh-Polypeptide-95 Pentapeptide-63 Oligopeptide-163 Sh-Polypeptide-6) Dimer is allowed for use in cosmetic products in the European Union under Regulation 1223/2009. It is not subject to a specific Annex restriction at the time of writing.
Frequently asked questions
What is R-(Sh-Polypeptide-111 Oligopeptide-163 Sh-Polypeptide-117 Sh-Polypeptide-94 Sh-Polypeptide-95 Pentapeptide-63 Oligopeptide-163 Sh-Polypeptide-6) Dimer?
R-(Sh-Polypeptide-111 Oligopeptide-163 Sh-Polypeptide-117 Sh-Polypeptide-94 Sh-Polypeptide-95 Pentapeptide-63 Oligopeptide-163 Sh-Polypeptide-6) Dimer is a cosmetic ingredient catalogued in the EU CosIng database. This peptide is a dimer linked by a disulfide bridge between the cysteines, consisting of a single chain synthetic fusion peptide, produced by fermentation in Chinese Hamster Ovary (CHO). The starting gene is synthesized by the fusion of the gene from sh-Polypeptide-111, Oligopeptide-163, sh-Polypeptide-117, sh-Polypeptide-94, sh-Polypeptide-95, and Pentapeptide-63. This fusion protein binds to Immunoglobulin E (IgE) and Interleukin-10 (IL-10) receptors; and it contains 605 amino acids which may contain disulfide bonds and/or glycosylation, and consists of the proper sequence of the 20 amino acids.
Is R-(Sh-Polypeptide-111 Oligopeptide-163 Sh-Polypeptide-117 Sh-Polypeptide-94 Sh-Polypeptide-95 Pentapeptide-63 Oligopeptide-163 Sh-Polypeptide-6) Dimer allowed in cosmetics in the EU?
Yes. R-(Sh-Polypeptide-111 Oligopeptide-163 Sh-Polypeptide-117 Sh-Polypeptide-94 Sh-Polypeptide-95 Pentapeptide-63 Oligopeptide-163 Sh-Polypeptide-6) Dimer is allowed for use in cosmetic products in the EU under Regulation 1223/2009.
What does R-(Sh-Polypeptide-111 Oligopeptide-163 Sh-Polypeptide-117 Sh-Polypeptide-94 Sh-Polypeptide-95 Pentapeptide-63 Oligopeptide-163 Sh-Polypeptide-6) Dimer do in cosmetic products?
R-(Sh-Polypeptide-111 Oligopeptide-163 Sh-Polypeptide-117 Sh-Polypeptide-94 Sh-Polypeptide-95 Pentapeptide-63 Oligopeptide-163 Sh-Polypeptide-6) Dimer is declared in the EU cosmetic ingredient inventory with these functions: skin conditioning, skin conditioning - emollient, skin protecting.
Related ingredients
Source: EU CosIng database (European Commission). This page is derived from public-sector information published by the European Commission. · Last updated: 25/04/2019